Research Data Repository of Saxon Universities

OPARA is the Open Access Repository and Archive for Research Data of Saxon Universities.


Researchers of Saxon Universities can either publish their research data on OPARA, or archive it here to comply with requirements of funding acencies and good scientic practice, without public access.

You can find the documentation of this service at the ZIH Data Compendium websites. If you need suppourt using OPARA please contact the Servicedesk of TU Dresden.

Please note: The OPARA service was recently upgraded to a new technical platform (this site). Previously stored data will not be available here immediately. It can be found at the still active old version of OPARA. These stock data will be migrated in near future and then the old version of OPARA will finally be shut down. Existing DOIs for data publications remain valid.

Artwork based on 1, 2, 3, 4  @pixabay
 

Communities in OPARA

Select a community to browse its collections.

Recent Submissions

Item
Open Access
Data for "Left-Right Husimi Representation of Chaotic Resonance States: Invariance and Factorization"
(Technische Universität Dresden, 2025-11-07) Lorenz, Florian; Schmidt, Jan Robert; Ketzmerick, Roland
This is the data for the figures in the paper "Left-Right Husimi Representation of Chaotic Resonance States: Invariance and Factorization" (New Journal of Physics 2025, arXiv:2507.10431 [nlin.CD]).
Item
Open Access
Geometric-Semantic-Model and Platform for pavement loading and response monitoring of a German Highway
(Technische Universität Dresden, 2025-11-06) Crampen, David; Hartung, Felix; Effkemann, Christoph; Becker, Ralf; Blankenbach, Jörg
This data publication contains the data and derivatives corresponding to the geometric-semantic model generated as foundation for the interactive visualization of the Unreal engine-based digital shadow platform for sensor data management and simulation integration for the use case Weigh-in-Motion (WIM) and pavement response analysis. The Demonstrator "3D Interactive Visualization and Physical Mockup of a WIM Research Site" of the DFG Collaborative Research Center SFB/TRR 339 “Digital Twin Road” represents a case study for evaluating the feasibility of integrating multiple monitoring subsystems into a single source of truth representing the main components of a digital shadow system. The system integrates WIM system measurements, simulated pavement deformations and a real-time connection to a small-scale physical mock-up, where vehicle positions and proxy vehicle loading measurements can be monitored in real time. This demonstrates the feasibility of sensor data integration into a single-source-of-truth and linkage of real-time capable pavement analysis simulations into a high fidelity 3D monitoring environment, allowing interaction with the physical environment.
Item
Open Access
Dataset for "Targeted, receptor-mediated delivery of a masked ᴅ-amino acid cell penetrating peptide for cell-specific phototoxicity"
(Universität Leipzig, 2025-11-06) List, Moritz; Jülke, Eva-Maria; Beck-Sickinger, Annette G.
Photodynamic therapy is an innovative treatment option for cancer, but current approaches are limited by poor tumor selectivity and low uptake. Here, we introduce a novel concept for a targeted phototoxic peptide, in which a lysosomally activatable payload is delivered selectively by receptor-mediated endocytosis. For the payload, 6-carboxytetramethylrhodamine (TMR) was attached to an activatable cell penetrating peptide. The regular activity of the CPP was blocked by electrostatic interactions with a poly-glutamate sequence but could be restored through cleavage by the lysosomal protease cathepsin B both in vitro and in cells. The unmasked CPP can then bind to the negatively charged lysosomal membrane, and upon irradiation, TMR generates reactive oxygen species (ROS) that disrupt the integrity of the membrane. This leads to a release of lysosomal contents into the cytosol which subsequently induces cell death. To achieve targeted delivery, the activatable payload was conjugated to chemerin-9, a high-affinity ligand for the chemokine-like receptor 1 (CMKLR1), a G protein-coupled receptor overexpressed in various cancers. Through this receptor-targeted approach, the peptide accumulates in CMKLR1-expressing cells while the lysosomal activation completely prevented off-target toxicity. Notably, this strategy enables even a weak photosensitizer like TMR to achieve potent cytotoxicity through lysosomal targeting. This approach represents an advancement in improving the selectivity and efficacy of photodynamic therapy and holds promise for the development of novel cancer therapies. Furthermore, the concept opens possibilities for specific intracellular delivery of peptides or proteins.
Item
Open Access
Supplementary data for: Weighted Shapley values and allocation of portfolio risk: One approach to solve the low-risk puzzle?
(Universität Leipzig, 2025-11-05) Hiller, Tobias
The data set contains data for the article “Weighted Shapley values and allocation of portfolio risk: One approach to solve the low-risk puzzle?”. This includes a description of the simulation settings, the Excel macros for calculating the results in the case of equal shares and random asset shares, and the 100,000 simulation results for both cases in Excel. Abstract of the paper: In this article, we extend the application of cooperative game theory to solve the so-called low-risk puzzle. Specifically, we apply concepts that consider asset weights in the allocation of portfolio risk. These weights can take into account various asset characteristics (e.g., image, popularity of an asset, corporate social responsibility, innovative strength) that have not been previously considered in portfolio risk allocation using cooperative game theory. We demonstrate the application through a simulation study. Our results show that considering assets weights could deliver added value when solving the low-risk puzzle.
Item
Open Access
Measuring active fluctuations of the cortex in mitosis by embedding an AFM cantilever pyrimidal tip
(Technische Universität Dresden, 2025-11-04) Narinder, Narinder; Elisabeth, Fischer-Friedrich
Living cells exhibit non-equilibrium dynamics emergent from the intricate interplay between molecular motor activity and its viscoelastic cytoskeletal matrix. The deviation from thermal equilibrium can be quantified through frequency-dependent effective temperature or time-reversal symmetry breaking quantified e.g. through the Kullback-Leibler divergence. Here, we investigate the fluctuations of an AFM tip embedded within the active cortex of mitotic human cells with and without perturbations that reduce cortex activity through inhibition of material turnover or motor proteins. While inhibition of motor activity significantly reduces both effective temperature and time irreversibility, inhibited material turnover leaves the effective temperature largely unchanged but lowers the time irreversibility and entropy production rate. Our experimental findings in combination with a minimal model highlight that time irreversibility, effective temperature and entropy production rate can follow opposite trends in active living systems, challenging in particular the validity of effective temperature as a proxy for the distance from thermal equilibrium. Furthermore, we propose that the strength of thermal noise and the occurrence of time-asymmetric deflection spikes in the dynamics of regulated observables are inherently coupled in living systems, revealing a previously unrecognized link between entropy production and time irreversibility.