Browsing by Author "Kempermann, Gerd"

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  • ItemOpen Access
    Behavioral data from the Individuality paradigm
    (Technische Universität Dresden, 2025-12-08) Kempermann, Gerd
    The data sets contain pre-processed raw data of antenna contacts of mice cohorts living within the Individuality set-up (ColonyRack), i.e. 70 connected cages that provide one large enriched environment. The data sets contain raw and processed data from antenna contacts that the mice made across the experimental period. The R package 'ColonyTrack' (https://rupertoverall.net/ColonyTrack/) was used to generate the data, which are presented in the compressed RData format. The two files contain the data for all individual mice in the experiments of both genotypes, Cyclin D2 knockouts and wildtypes with all spatial and temporal coordinates along with the mouse IDs.
  • ItemOpen Access
    RNAseq data for Hassani et al. "Environmental enrichment regulates inter-individual transcriptional variance in the hippocampus"
    (Technische Universität Dresden, 2026-09-28) Kempermann, Gerd; Rünker, Annette
    Genetically identical mice housed in the same enriched environment (ENR) develop divergent behavioural trajectories associated with differences in adult hippocampal neurogenesis and brain-wide connectivity. We asked whether such inter-individual differences are also reflected in the hippocampal transcriptome—not only as shifts in mean expression, but as effects on within-group variability. Analysing bulk hippocampal RNA-seq from isogenic standard- (STD) and ENR-housed mice, we identified highly variable genes (HVGs) that segregated into common, STD-specific and ENR-specific subsets. ENR did not uniformly increase transcriptional variability: it reduced highest variability in neuron-projection and synapse genes, while maintaining or increasing it in genes linked to extracellular matrix organization and oxidative phosphorylation. Mapped onto a WGCNA-derived ENR co-expression reference, HVGs were unevenly distributed across modules and concentrated at module hubs. Hub architecture and the position of non-hub HVGs differed between modules, corresponding to distinct functional programs: synaptic and chromatin-associated in two, RNA-processing and splicing in a third. Synaptic enrichment in STD-specific HVGs, extracellular-matrix enrichment in common HVGs and module-level localisation were stable across selection thresholds (5–20%). Hippocampal transcriptional variability is thus non-random, functionally coherent, embedded in co-expression architecture and shaped by environmental experience—suggesting it is an undervalued activity-dependent variable in the regulation of brain plasticity.