Browsing by Author "Kleemann, Hans"

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  • ItemOpen Access
    Conductive Hydrogels for Exogenous Sensing and Cell Fate Control
    (Technische Universität Dresden, 2026-03-09) Akbar, Teuku Fawzul; Jimenez-Rodriguez, Carlos Alejandro; Biktimirova, Railia; Hermes, Ilka; Kurth, Thomas; Pham, My Duyen; Tsurkan, Mikhail; Friedrichs, Jens; Morgan, Francis L. C.; Kleemann, Hans; Guskova, Olga; Freudenberg, Uwe; Fratzl, Peter; Werner, Carsten; Tondera, Christoph; Minev, Ivan R.
    Next generation technologies linking living systems to computers will require materials built on biology, an approach that may address persistent challenges in stable and multimodal information exchange. Here, we present a semi-synthetic hydrogel, designed to emulate key features of native extracellular matrix (ECM) while offering electrically tunable functionality. We engineer interactions between sulfated glycosaminoglycans (sGAGs) and a semiconducting organic polymer (Poly(3,4-ethylenedioxythiophene), PEDOT) within a soft hydrogel network (PEDOT:sGAGh). We demonstrate control over the material’s nanoarchitecture, electrochemical behavior, and biomolecular interactions. In particular, PEDOT:sGAGh exhibits affinity for bioactive proteins, including growth factors, and allows their release or retention to be modulated by low-voltage stimulation. This enables electrical control over macromolecular cues for cell differentiation, a capability not found in natural ECM or conventional conductive hydrogels. These functions are achieved with ultra-low PEDOT content (≈ 1 wt.%), preserving the hydrogel’s tissue-like softness and high water content. The PEDOT:sGAGh material can be integrated as a bioactive coating on electrodes, or into three dimensional organic electrochemical transistors (OECTs). Our results position PEDOT:sGAGh as a versatile platform for realizing biohybrid circuits that bridge molecular signaling and solid-state electronics, thus paving the way for brain-machine interfaces that operate beyond purely electrical modes of interaction.
  • ItemOpen Access
    FAVORS - Measurements Q1/2025 - In Vivo Impedance Measurements on Anastomotic Tissue in 7 Different Anastomoses in the Small Intestine of a German Landrace Pig
    (Technische Universität Dresden, 2025-11-25) Jaekel, Finn; Kantelberg, Richard; Kleemann, Hans
    This dataset contains all experimental data from the in vivo measurements on 29th and 30th January 2025 at the University Hospital Rostock, Institute for Experimental Surgery, in the scope of the FAVORS Project. Impedance measurements were performed on an implanted sensor ring inside of 7 different anastomoses in the small intestine of a German Landrace Pig.