Technische Universität Dresden

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Browsing Technische Universität Dresden by Subject "2"

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  • ItemOpen Access
    Measuring active fluctuations of the cortex in mitosis by embedding an AFM cantilever pyrimidal tip
    (Technische Universität Dresden, 2025-11-04) Narinder, Narinder; Elisabeth, Fischer-Friedrich
    Living cells exhibit non-equilibrium dynamics emergent from the intricate interplay between molecular motor activity and its viscoelastic cytoskeletal matrix. The deviation from thermal equilibrium can be quantified through frequency-dependent effective temperature or time-reversal symmetry breaking quantified e.g. through the Kullback-Leibler divergence. Here, we investigate the fluctuations of an AFM tip embedded within the active cortex of mitotic human cells with and without perturbations that reduce cortex activity through inhibition of material turnover or motor proteins. While inhibition of motor activity significantly reduces both effective temperature and time irreversibility, inhibited material turnover leaves the effective temperature largely unchanged but lowers the time irreversibility and entropy production rate. Our experimental findings in combination with a minimal model highlight that time irreversibility, effective temperature and entropy production rate can follow opposite trends in active living systems, challenging in particular the validity of effective temperature as a proxy for the distance from thermal equilibrium. Furthermore, we propose that the strength of thermal noise and the occurrence of time-asymmetric deflection spikes in the dynamics of regulated observables are inherently coupled in living systems, revealing a previously unrecognized link between entropy production and time irreversibility.
  • ItemOpen Access
    Raw data of the paper "Brillouin spectroscopic investigation of corneal hydration and the impact of cross-linking therapy on water retention"
    (Technische Universität Dresden, 2025-03-06) Rix, Jan; Steuer, Svea
    Raw Brillouin, Raman and PS-OCT data acquired within the project and paper "Brillouin spectroscopic investigation of corneal hydration and the impact of cross-linking therapy on water retention"
  • ItemOpen Access
    SMELLODI_Deliverable_D5-5-Dataset of BOV description matrix
    (Technische Universität Dresden, 2024-09-06) Power Guerra, Nicole
    Deliverable D5.5 shows the dataset of body odor volatilome (BOV) description matrix of healthy/sick BOV. The BOV description matrix was adapted from the description matrix developed in T2.2 (D2.3, D2.4). Female subjects (human raters) discriminated, rated, and evaluated body odors (BO) from healthy and sick donors. The BO donors were described in D5.2 and included patients with Parkinson’s disease (PD), mild cognitive impairment (MCI), COVID-19 infection (COVID sick), and with a common cold. The human raters successfully distinguished and identified BOs associated with illness (D.5.4).