Printing-assisted Integration of Thermal, Fluidic and Electrical Components in Implants for Focal Brain Cooling - Publication Data
Documentation of the data | Specific documentation of data provided via READMEs packed with individual datasets. | |
References to related material | Printing-assisted Integration of Thermal, Fluidic and Electrical Components in Implants for Focal Brain Cooling | |
Description of the data | Specific description of data provided via READMEs packed with individual datasets. | |
Type of the data | Collection | |
Total size of the dataset | 47392600196 | |
Author | Moore, Spencer Ryan | |
Author | King, Naomi | |
Author | Da Silva, Arua Clayton | |
Author | Howarth, Clare | |
Author | Berwick, Jason | |
Author | Paterson, Thomas E. | |
Author | Minev, Ivan R. | |
Upload date | 2026-09-23T12:22:28Z | |
Publication date | 2026-09-23T12:22:28Z | |
Data of data creation | 2026-08-20 | |
Publication date | 2026-09-23 | |
Abstract of the dataset | Complete dataset for the publication "Printing-assisted Integration of Thermal, Fluidic and Electrical Components in Implants for Focal Brain Cooling". Contained within is the raw In Vitro and In Vivo experimental data; neural signal processing scripts; and data visualisation code for each figure graph in the publication. Implant G-code for each version of the design can be used to print a replica system using the RegenHU 3D Discovery bioprinter or adapt the code to another printer system. Hardware schematics and firmware code is provide for the manufacture the Auxiliary Driver hardware to support implant operations. | |
Public reference to this page | https://opara.zih.tu-dresden.de/handle/123456789/2909 | |
Public reference to this page | https://doi.org/10.25532/OPARA-1560 | |
Publisher | Technische Universität Dresden | |
Licence | Attribution 4.0 International | en |
URI of the licence text | http://creativecommons.org/licenses/by/4.0/ | |
Specification of the discipline(s) | 4::44::407::407-06 | |
Title of the dataset | Printing-assisted Integration of Thermal, Fluidic and Electrical Components in Implants for Focal Brain Cooling - Publication Data | |
Research instruments | 3D Discovery r5, RegenHU | |
Research instruments | PARSTAT3000, AMETEK | |
Research instruments | ARM-310CE, Thinky Corporation | |
Research instruments | U5855A v1.30 (Serial No. JP54461364), Keysight | |
Research instruments | D16-20mm-100-177, Neuronexus | |
Research instruments | i-STAT 1 Blood Gas Analyser w CG8 cartridges, Abbott | |
Research instruments | Stereotatic Frame, Kopf Instruments, California | |
Research instruments | Medusa Bioamp RA16PA, Tucker-Davis-Technologies | |
Research instruments | RZ5, Tucker-Davis-Technologies | |
Software | MATLAB r2024b | |
Software | LabVIEW 2023 | |
Software | Python 3.9 | |
Software | Keil uVision v5.38a | |
Software | KiCAD 6.0.9 | |
Software | BioCAD v1.1 | |
Software | TrueIR Studio Analysis and Reporting Tool 2.0.60920.01 | |
Software | VersaStudio 2.60.2 | |
Software | COMSOL Multiphysics 5.5 | |
Software | Inkscape 1.4.2 | |
Software | Blender 5.0 | |
Project abstract | The limitations of electrical neuromodulation are driving the development of neuroprosthetic systems enhanced with complementary modalities. A key technological challenge however remains the integration of the necessary hardware components (optical, thermal, fluidic, electrical) into miniaturized implants. Here we present a design framework, inspired by fast prototyping, that promises to reduce the complexity, fabrication time, and device bulk of multimodal neural interface systems. By combining extrusion-based 3D printing of silicones and discrete electronic components, we integrated thermal neuromodulation and electrical recording capabilities in soft packages suitable for placement on the cortical surface of rodents. When linked to an autonomous auxiliary driver unit, these packages establish rapid, stable and localized hypothermia together with ElectroCorticoGraphy (ECoG) recording. In a rodent model of epilepsy (4-aminopyridine), we demonstrate hypothermia-induced suppression of seizure-like activity. Our approach may advance the clinical translation of focal hypothermia as an alternative therapy for drug-resistant focal epilepsies. | |
Funding Acknowledgement | Funding received from the European Research Council (ERC) under the Horizon 2020 EU.1.1. - Excellent Science Programme - IntegraBrain (804005) | |
Public project website(s) | https://cordis.europa.eu/project/id/804005 | |
Public project website(s) | https://www.europeandissemination.eu/integrabrain-project-dr-ivan-minev/4756 | |
Project title | Printing-assisted Integration of Thermal, Fluidic and Electrical Components in Implants for Focal Brain Cooling |
Files
Original bundle
- Name:
- Dataset_Printing-assisted_Integration_of_Thermal,_Fluidic_and_Electrical_Components_in Implants_for_Focal Brain_Cooling.zip
- Size:
- 44.14 GB
- Format:
- Description:
- ZIP file containing the complete paper dataset. This includes; raw neurological recordings, process neurological data, data processing scripts, hardware schematics, firmware programmes, data collection & control GUI programmes, stimulation files, setup diagrams, and 3D models. A top level README file can be found upon entering the Folder that contains a folder structure tree to aid in dataset navigation. As you navigate through the folders, README files can be found relating to that specific section, data, or figure element. Code and scripts are commented thoroughly to aid in understanding its operation or data handling/format.
License bundle
- Name:
- license.txt
- Size:
- 3.86 KB
- Format:
- Item-specific license agreed to upon submission
- Description:
Collections
