Optoacoustic Imaging in Lower Extremity Revascularization: A Novel Technique to Assess Perioperative Muscle Perfusion
Type of the data | Dataset | |
Total size of the dataset | 42616 | |
Author | Winther, Birte | |
Upload date | 2025-06-10T16:13:41Z | |
Publication date | 2025-06-10T16:13:41Z | |
Publication date | 2025-06-10 | |
Abstract of the dataset | This Excel sheet contains perfusion measurements acquired using Multispectral Optoacoustic Tomography (MSOT) from a cohort of 26 patients undergoing lower extremity revascularization. Measurements were taken at three time points: before the procedure (pre), immediately after the procedure (post), and before hospital discharge (disch). For each patient (identified by a pseudonym in the leftmost column), multiple oxygenation-related parameters were recorded at various wavelengths, targeting three anatomical regions of interest: Tibialis Anterior Muscle – Proximal (TAP), Tibialis Anterior Muscle – Medial (TAM), and Flexor Hallucis Brevis Muscle (FH). | |
Public reference to this page | https://opara.zih.tu-dresden.de/handle/123456789/1409 | |
Public reference to this page | https://doi.org/10.25532/OPARA-809 | |
Publisher | Universität Leipzig | |
Licence | Attribution-ShareAlike 4.0 International | en |
URI of the licence text | http://creativecommons.org/licenses/by-sa/4.0/ | |
Specification of the discipline(s) | 2::22::205::205-12 | |
Title of the dataset | Optoacoustic Imaging in Lower Extremity Revascularization: A Novel Technique to Assess Perioperative Muscle Perfusion | |
Project abstract | Objectives: This study aimed to assess the feasibility of Multispectral Optoacoustic Tomography (MSOT) in evaluating changes in oxygenated hemoglobin (HbO2) levels in the tibialis anterior (TA) and flexor hallucis brevis muscles (FH) before and after lower extremity revascularization (LER). Background: Perfusion in peripheral artery disease (PAD) patients is typically assessed with ankle-brachial-index, duplex ultrasound, or angiography. However, no standardized tool currently measures microperfusion, which is vital for diagnosing PAD, monitoring progression, and assessing wound healing. Methods: In this proof-of-concept study, 26 patients with PAD who underwent LER between January and August 2024 were included. HbO2 levels in the TA and FH were evaluated with MSOT before and directly after LER, with additional measurements performed before discharge in a subgroup of patients. Primary patency and symptom control were assessed at 3 months and up to 6 months post-procedure. Results: Overall, a statistically significant difference in HbO2 levels was observed between pre- and post-LER in the TA and FH. In 10 patients, HbO2 levels did not increase following LER, and at the 6-month follow-up, 2 of these patients required target lesion revascularization (TLR). In contrast, 16 patients demonstrated increased HbO2 levels post-LER, with no patients requiring TLR at 6-months. Conclusion: MSOT is a non-invasive, radiation-free, and label-free modality for real-time assessment of microcirculatory perfusion. In this study, MSOT exhibited its sensitivity to changes in muscle and tissue perfusion following LER, suggesting its potential as a novel diagnostic tool for evaluating LER outcomes. | |
Project title | Optoacoustic Imaging in Lower Extremity Revascularization: A Novel Technique to Assess Perioperative Muscle Perfusion |
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