TU Dresden Data Publications
Permanent URI for this collectionhttp://opara.zih.tu-dresden.de/handle/123456789/15
Data publications from research of Dresden University of Technology.
Browse
Browsing TU Dresden Data Publications by Subject "2"
Now showing 1 - 10 of 10
- Results Per Page
- Sort Options
Item Open Access Behavioral data from the Individuality paradigm(Technische Universität Dresden, 2025-12-08) Kempermann, GerdThe data sets contain pre-processed raw data of antenna contacts of mice cohorts living within the Individuality set-up (ColonyRack), i.e. 70 connected cages that provide one large enriched environment. The data sets contain raw and processed data from antenna contacts that the mice made across the experimental period. The R package 'ColonyTrack' (https://rupertoverall.net/ColonyTrack/) was used to generate the data, which are presented in the compressed RData format. The two files contain the data for all individual mice in the experiments of both genotypes, Cyclin D2 knockouts and wildtypes with all spatial and temporal coordinates along with the mouse IDs.Item Open Access Chaperones Skp and SurA dynamically expand unfolded OmpX and synergistically disassemble oligomeric aggregates(Technische Universität Dresden, 2022-02-01) Schlierf, MichaelThe packages contain the raw data (.ht3 and BIN files) obtained for all smFRET and FCS measurements mentioned in the manuscript titled "Chaperones Skp and SurA dynamically expand unfolded OmpX and synergistically disassemble oligomeric aggregates." The data were acquired using a custom-built setup combining confocal singe-molecule spectroscopy with time-correlated single-photon counting (TCSPC), pulsed interleaved excitation (PIE), and fluorescence anisotropy detection for multiparameter-flourescence detection (MFD).Item Open Access Evolution and adaptations of the seminal proteome in an insect with traumatic insemination(Technische Universität Dresden, 2026-04-14) Garlovsky, MartinThe protein composition of sperm and seminal fluid are key to male fitness. However, we currently lack an understanding of the factors that shape seminal proteome composition. The common bedbug (Cimex lectularius) mates by traumatic insemination, subjecting the ejaculate to a unique selective environment as sperm traverse the female genital and paragenital system. We provide the first high-throughput proteomic characterisation of the sperm and seminal fluid proteome in a hemimetabolous insect and the first in-depth proteomic characterisation of the male bedbug reproductive system. Our analysis revealed conserved and unique features of the sperm and seminal fluid proteome with possible links to features of sperm behaviour linked to traumatic insemination. The sperm proteome showed elevated rates of molecular evolution, unlike most other studied species. Conversely, the sperm proteome also contained many conserved proteins. Notably, we found an expansion of Sperm-leucylaminopeptidases (S-Laps) in bedbugs and other hemimetabolous insects, suggesting the origin of S-Laps is perhaps even more ancient than previously thought. Using in silico protein-ligand binding predictions, we show that S-Laps have likely retained catalytic activity. Our results provide a list of candidate proteins involved in reproduction and a useful resource for future studies of this expanding global pest.Item Open Access HeLa metaphase spindle tomographic data sets and analysis(Technische Universität Dresden, 2021-09-02) Kiewisz, RobertThis collection of datasets belongs to the eLife paper titled "Three-dimensional structure of kinetochore-fibers in human mitotic spindles": The collection includes all raw datasets of three HeLa Kyoto metaphase cells, that were acquired using electron tomography technique. This collection is also included all processed data as well as analysis as were shown in the publication.Item Open Access HeLa metaphase spindle tomographic data sets and analysis for z-expansion data(Technische Universität Dresden, 2022-05-09) Kiewisz, Robert3D tomographic model of HeLa cell obtained with 300kV TEMItem Open Access Measuring active fluctuations of the cortex in mitosis by embedding an AFM cantilever pyrimidal tip(Technische Universität Dresden, 2025-11-04) Narinder, Narinder; Elisabeth, Fischer-FriedrichLiving cells exhibit non-equilibrium dynamics emergent from the intricate interplay between molecular motor activity and its viscoelastic cytoskeletal matrix. The deviation from thermal equilibrium can be quantified through frequency-dependent effective temperature or time-reversal symmetry breaking quantified e.g. through the Kullback-Leibler divergence. Here, we investigate the fluctuations of an AFM tip embedded within the active cortex of mitotic human cells with and without perturbations that reduce cortex activity through inhibition of material turnover or motor proteins. While inhibition of motor activity significantly reduces both effective temperature and time irreversibility, inhibited material turnover leaves the effective temperature largely unchanged but lowers the time irreversibility and entropy production rate. Our experimental findings in combination with a minimal model highlight that time irreversibility, effective temperature and entropy production rate can follow opposite trends in active living systems, challenging in particular the validity of effective temperature as a proxy for the distance from thermal equilibrium. Furthermore, we propose that the strength of thermal noise and the occurrence of time-asymmetric deflection spikes in the dynamics of regulated observables are inherently coupled in living systems, revealing a previously unrecognized link between entropy production and time irreversibility.Item Open Access Novel female reproductive organ differentiates postmating transcriptional response to insemination versus arrival of sperm in bedbugs(Technische Universität Dresden, 2026-03-17) Garlovsky, MartinFollowing the evolution of internal fertilisation, the female reproductive tract became the site of reproductive interactions. However, our understanding of the evolution of female reproductive tract function, including postmating responses critical for reproductive success, are taxonomically limited. Traumatic insemination in the common bedbug (Cimex lectularius) presents an unusual scenario under which postmating responses unfold. Bedbugs have evolved a novel organ, the mesospermalege, that is the site of initial ejaculate × female interactions. As the female reproductive tract does not take receipt of the ejaculate until several hours after mating, bedbugs provide a unique opportunity to explore the evolution of a novel reproductive organ that decouples postmating female responses involved in mating and transfer of the ejaculate from sperm storage, ovulation, and oviposition. Here we show that the mesospermalege has a gene expression profile consistent with functions of ejaculate processing and immune response normally found in the lower reproductive tract of other insect species. In parallel, the postmating response in the lower female reproductive tract is delayed, coinciding with movement of sperm through the female, clearly showing that the postmating response has evolved in response to sperm receipt rather than being an innate function of the tissue. Notably, we also found expression of male seminal fluid genes in the mesospermalege, indicating that intersexual molecular dynamics influence the evolution of reproductive tissues. Our results provide insights into the evolution of novel reproductive traits and female postmating physiology in a global pest with an unusual reproductive biology.Item Open Access Raw data of the paper "Brillouin spectroscopic investigation of corneal hydration and the impact of cross-linking therapy on water retention"(Technische Universität Dresden, 2025-03-06) Rix, Jan; Steuer, SveaRaw Brillouin, Raman and PS-OCT data acquired within the project and paper "Brillouin spectroscopic investigation of corneal hydration and the impact of cross-linking therapy on water retention"Item Open Access SMELLODI_Deliverable_D5-5-Dataset of BOV description matrix(Technische Universität Dresden, 2024-09-06) Power Guerra, NicoleDeliverable D5.5 shows the dataset of body odor volatilome (BOV) description matrix of healthy/sick BOV. The BOV description matrix was adapted from the description matrix developed in T2.2 (D2.3, D2.4). Female subjects (human raters) discriminated, rated, and evaluated body odors (BO) from healthy and sick donors. The BO donors were described in D5.2 and included patients with Parkinson’s disease (PD), mild cognitive impairment (MCI), COVID-19 infection (COVID sick), and with a common cold. The human raters successfully distinguished and identified BOs associated with illness (D.5.4).Item Open Access Supplementary data for manuscript "Quantitation of free glycation compounds in saliva" PLOS ONE(Technische Universität Dresden, 2019-07-26) Manig, FriederikeRaw data of salivary concentrations of glycation compounds; method validation data, Relevant raw data MRP in saliva (PLOS ONE)