Type of the data datacite.resourceTypeGeneral	Dataset
Total size of the dataset datacite.size	68689108717
Author dc.contributor.author	Rix, Jan
Author dc.contributor.author	Steuer, Svea
Upload date dc.date.accessioned	2025-03-06T07:16:12Z
Publication date dc.date.available	2025-03-06T07:16:12Z
Publication date dc.date.issued	2025-03-06
Abstract of the dataset dc.description.abstract	Raw Brillouin, Raman and PS-OCT data acquired within the project and paper "Brillouin spectroscopic investigation of corneal hydration and the impact of cross-linking therapy on water retention"
Public reference to this page dc.identifier.uri	https://opara.zih.tu-dresden.de/handle/123456789/1294
Public reference to this page dc.identifier.uri	https://doi.org/10.25532/OPARA-750
Publisher dc.publisher	Technische Universität Dresden
Licence dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 International	en
URI of the licence text dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
Specification of the discipline(s) dc.subject.classification	2
Title of the dataset dc.title	Raw data of the paper "Brillouin spectroscopic investigation of corneal hydration and the impact of cross-linking therapy on water retention"
Project abstract opara.project.description	Recently, Brillouin spectroscopy has been proposed as a promising non-invasive tool to evaluate corneal biomechanics, e.g. during corneal cross-linking (CXL) treatment. However, the impact of corneal hydration on the Brillouin shift hampers straightforward interpretation of the measurements, especially when judging on the success of the CXL procedure. Therefore, in this work, we first quantify the effect of corneal (de)hydration on the Brillouin shift revealing that reliable measurements are only possible under constant hydration conditions, which was subsequently achieved by immersing porcine eyes in solution and waiting until an equilibrium state was reached. Investigations showed that Brillouin spectroscopy evaluates the CXL effect mainly indirectly via reduced water uptake, while polarization-sensitive optical coherence tomography evaluates the CXL effect directly via changes in collagen fiber alignment and is therefore insensitive to corneal hydration. Raman spectroscopy is not indicating any alterations in the molecular structure revealing that new cross-links are not created due to the CXL procedure. Compared to large water retention in balanced salt solution, the missing water uptake in dextran-based (16%) solution hampers the evaluation of the CXL effect by Brillouin spectroscopy.
Project title opara.project.title	Brillouin spectroscopic investigation of corneal hydration and the impact of cross-linking therapy on water retention

Raw data of the paper "Brillouin spectroscopic investigation of corneal hydration and the impact of cross-linking therapy on water retention"

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