Data for a Meta-Analysis of Oxytocin’s Neural Effects on Social Behavior Networks in Mental Health Disorders

Baulig, Hannah Maria

Data for a Meta-Analysis of Oxytocin’s Neural Effects on Social Behavior Networks in Mental Health Disorders

Contributing person datacite.contributor.Supervisor	Evelyn Muschter
Contributing person datacite.contributor.Supervisor	Lara Maliske
Documentation of the data datacite.description.TechnicalInfo	The dataset is fully documented through: Top-level README.md: Overview of dataset structure, methods, software, and folder contents. META folder: Contains study-level CSV files and meta_description.json explaining all column names. SDM folder: Contains all SDM-PSI outputs for the main and subgroup analyses, including NIfTI maps, plots, and extracted effect sizes. Scripts folder: MATLAB scripts with embedded documentation describing how to reproduce the preprocessing, coordinate conversion, and SDM table creation. All data files are accompanied by metadata to ensure transparency and reproducibility. Non-open-access PDFs of original studies have been removed; DOIs are provided for traceability.
Description of the data datacite.resourceType	This dataset contains the complete study-level data and analysis outputs used in a coordinate-based meta-analysis examining the neural effects of oxytocin during social tasks across mental health disorders. The data include metadata extracted from published fMRI studies, such as diagnostic groups, social task characteristics, study design information, sample demographics, and oxytocin administration details. Peak activation coordinates were extracted for both whole-brain and region-of-interest (ROI) analyses and converted into a standardized format for SDM-PSI processing. The dataset further contains all statistical outputs generated with SDM-PSI 6.23beta, including voxel-wise effect size maps, thresholded significance maps (NIfTI), extracted effect sizes, SDM tables, plots, and log files for main and subgroup analyses. These analyses include disorder-specific contrasts, social task contrasts, dose-dependent meta-regressions, and analyses aligned with the RDoC social constructs. To support reproducibility, all MATLAB scripts used to generate the metadata tables, convert coordinate formats, and prepare SDM-compatible input files are included. The project follows open science principles, using standardized folder structures and detailed metadata. No raw neuroimaging images were available in the original studies; therefore, this dataset exclusively contains reported peak coordinates and derived statistical SDM-PSI outputs. Access to original studies is provided via DOI links; non–open-access PDFs were removed.
Type of the data datacite.resourceTypeGeneral	Dataset
Total size of the dataset datacite.size	128174114
Author dc.contributor.author	Baulig, Hannah Maria
Upload date dc.date.accessioned	2025-11-18T17:39:07Z
Publication date dc.date.available	2025-11-18T17:39:07Z
Data of data creation dc.date.created	2025-08
Publication date dc.date.issued	2025-11-18
Abstract of the dataset dc.description.abstract	This dataset contains the extracted and processed data from a coordinate-based meta-analysis (CBMA) investigating how oxytocin influences neural activity during social tasks across mental health disorders. It includes study-level metadata (e.g., disorder, task type, design characteristics, sample demographics, oxytocin dose) and all extracted peak coordinates for whole-brain and region-of-interest (ROI) analyses. In addition, it provides full SDM-PSI outputs such as NIfTI statistical maps, extracted effect sizes, plots, and SDM tables for both the main meta-analysis and all sub-analyses. MATLAB scripts used for data preprocessing, coordinate conversion, and SDM file creation are included to ensure transparency and reproducibility.
Public reference to this page dc.identifier.uri	https://opara.zih.tu-dresden.de/handle/123456789/1856
Public reference to this page dc.identifier.uri	https://doi.org/10.25532/OPARA-1020
Publisher dc.publisher	Technische Universität Dresden
Licence dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 International	en
URI of the licence text dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
Specification of the discipline(s) dc.subject.classification	1::12::110::110-02
Title of the dataset dc.title	Data for a Meta-Analysis of Oxytocin’s Neural Effects on Social Behavior Networks in Mental Health Disorders
Research instruments opara.descriptionInstrument	Published fMRI studies using clinical MRI scanners (various manufacturers and models); this dataset contains only secondary, published peak coordinate data, not primary imaging data.
Underlying research object opara.descriptionObject.People	Mental Health Conditions
Underlying research object opara.descriptionObject.Substance	Oxytocin
Underlying research object opara.descriptionObject.Tissue	Brain
Software opara.descriptionSoftware.Other	SDM-PSI 6.23beta
Software opara.descriptionSoftware.Other	MATLAB R2023b
Project abstract opara.project.description	This project examines how the neuropeptide oxytocin influences brain activity during social behavioral tasks across different mental health disorders. Using a meta-analysis of published neuroimaging studies, it identifies brain regions that consistently respond to oxytocin. The results highlight key areas involved in social cognition, such as the anterior cingulate cortex, while showing that effects vary depending on diagnosis, task type, and dosage. Overall, the findings help clarify how oxytocin may support social behavior and provide a basis for future research.
Project title opara.project.title	Targeting Social Behavior Networks in Mental Disorders: A Meta-Analysis of Oxytocin’s Neural Effects