Original Data (microscopic pictures, Western blots) - Alveolar epithelial junctions in early lung injury and COVID-19-induced fibrosis

Wiegner, Julián

Original Data (microscopic pictures, Western blots) - Alveolar epithelial junctions in early lung injury and COVID-19-induced fibrosis

Type of the data datacite.resourceTypeGeneral	Dataset
Total size of the dataset datacite.size	592539754983
Author dc.contributor.author	Wiegner, Julián
Upload date dc.date.accessioned	2026-03-30T14:37:26Z
Publication date dc.date.available	2026-03-30T14:37:26Z
Publication date dc.date.issued	2026-03-30
Abstract of the dataset dc.description.abstract	This data deposit contains all the raw data of the manuscript to the paper "The role of alveolar epithelial junctions in early lung injury and COVID-19-induced fibrosis" (see project abstract). The data is sorted by 3.1 to 3.4 corresponding to the headlines of the "Results" Section of the manuscript. 3.1 and 3.2 contain the raw microscopic pictures with corresponding negative controls devided by pathologic groups and the mRNA analysis data. 3.3 contains the raw microscopic pictures with corresponding negative controls named with different Treatments and the Western blots. 3.4 contains the raw microscopic pictures with corresponding negative controls of fluorescence and light microscopy.
Public reference to this page dc.identifier.uri	https://opara.zih.tu-dresden.de/handle/123456789/2132
Public reference to this page dc.identifier.uri	https://doi.org/10.25532/OPARA-1130
Publisher dc.publisher	Technische Universität Dresden
Licence dc.rights	CC0 1.0 Universal	en
URI of the licence text dc.rights.uri	http://creativecommons.org/publicdomain/zero/1.0/
Specification of the discipline(s) dc.subject.classification	2::22::205::205-06
Title of the dataset dc.title	Original Data (microscopic pictures, Western blots) - Alveolar epithelial junctions in early lung injury and COVID-19-induced fibrosis
Project abstract opara.project.description	The pathophysiology of a SARS-CoV-2 infection, causing COVID-19, has not yet been fully elucidated. Pulmonary histology shows diffuse alveolar damage with long-term disease possibly leading to fibrotic changes, driven through pro-remodelling factors. Damage of the alveolar epithelial barrier (formed by alveolar epithelial cells typ I, consisting of tight and adherens junctions) has been described as a key mechanism of early fibrosis and therefore could be crucial for post-acute sequelae of COVID-19 as well. Abundance and expression of proteins regulating intercellular contacts (caveolin-1, P2X7R) and of adherens junctions (p120 catenin) were investigated in FFPE-specimen of COVID-19 affected lungs (acute vs. chronic) compared to control and interstitial lung disease of other cause (n = 6 each), followed by further investigation of p120 catenin in early lung injury models using profibrotic agents in culture of murine lung and human alveolar epithelial cell culture.
Funding Acknowledgement opara.project.fundingAcknowledgement	This work was supported by the Deutsche Forschungsgemeinschaft (DFG), BA 3899/4-2. This work was funded by the research consortium NATON. The NATON project (grant number 01KX2121) is part of the National Network University Medicine (NUM), funded by Federal Ministry of Education and Research (BMBF) in Germany. The National Network University Medicine is coordinated by the Charité - Universitätsmedizin Berlin and supervised by the German Aerospace Center (DLR Project Management Agency).
Project title opara.project.title	The role of alveolar epithelial junctions in early lung injury and COVID-19-induced fibrosis