Research Data Repository of Saxon Universities

OPARA is the Open Access Repository and Archive for Research Data of Saxon Universities.


Researchers of Saxon Universities can either publish their research data on OPARA, or archive it here to comply with requirements of funding acencies and good scientic practice, without public access.

You can find the documentation of this service at the ZIH Data Compendium websites. If you need suppourt using OPARA please contact the Servicedesk of TU Dresden.

Please note: The OPARA service was recently upgraded to a new technical platform (this site). Previously stored data will not be available here immediately. It can be found at the still active old version of OPARA. These stock data will be migrated in near future and then the old version of OPARA will finally be shut down. Existing DOIs for data publications remain valid.

Artwork based on 1, 2, 3, 4  @pixabay
 

Communities in OPARA

Select a community to browse its collections.

Recent Submissions

Item
Open Access
Mesenchymal-epithelial transition reduces proliferation but increases immune evasion in tumor spheroids
(Technische Universität Dresden, 2025-05-23) Dimari, Gina; Hu, Yueyuan; Frenzel, Annika; Fuchs, Anke; Wurm, Alexander A.; Fischer-Friedrich, Elisabeth
The data corresponds to experiments performed with MET-inducible models of MDA-MB-231 and ES-2 mesenchymal cell lines. These were modified to contain an inducible plasmid that codes for miR-200c and miR-141 that upon overexpression trigger the expression of epithelial features. In the first place, the collection contains transcriptomic and proteomic data suchs as RNA seq data, q-PCR data, western-blot data, and immunofluorescence of EMT markers, that were all used to characterize our models. Moving forwards, with these two models we performed proliferation assays in adherent and 3D cultures of different nature. In adherent cultures, we looked at the effect of MET on proliferation focusing on the regulation exhorted by mechanical signals such as cell-cell junctions, spread area and their influence on contact inhibition of proliferation. Most of the data acquired from these experiments were obtained by image analysis of immunofluorescent microscopy. To measure proliferation changes in 3D cultures, we cultured cells in PEG-heparin hydrogels at both degradable and non-degradable forms. This gave rise to tumor spheroids were we quantified different parameters to assess proliferation levels. Moreover, we used pharmacologycal inhibitors to study the effect of focal adhesion and actomyosin cytoskeletal signaling in the proliferation of these tumor spheroids, culture in control and MET-inducing conditions. The data from these experiments was as well obtained from image analysis from fluorescent microscopy. Furthermore, we performed co-cultures of tumor spheroids with peripheral blood mononuclear cells and quantified the changes in apoptosis in the tumor cells, both by image analysis from immunofluorescent microscopy and flow cytometry.
Item
Open Access
Supplementary information to the publication “Influence of foam composite in lithium-ion battery packs on their mechanical recycling”
(Technische Universität Bergakademie Freiberg, 2025-05-23) Rademacher, Paul; Kaas, Alexandra; Wilke, Christian; Peuker, Urs A.
Supplementary data to the following paper. Lithium-ion batteries (LIB) make an important contribution to the energy transition as energy storage devices for mobile and stationary applications. The recovery of the valuable materials contained in the lithium-ion batteries after their end of life is of central importance for the development of a circular economy in line with the concept of sustainability. Mechanical recycling is to be seen as a first step in this process. With processes for the mechanical recycling of LIB that have already been successfully developed and implemented, it is possible to recover most components of a LIB i.e., the materials of the anode, cathode and separator foils as well as the casing. The concentrate of the coating of the electrode foils, which is called black mass, becomes an intermediate product for hydrometallurgical recycling processes for the recovery of lithium, among other materials. Some OEM of the automotive industry are about to introduce cell-to-pack-technologies, in which individual LIB-cells are fixed and stabilised in their position inside the large battery pack with the aid of a foam material, thereby adding further materials to the battery pack. The effects of the foam on the recycling are not known yet. Within the scope of this experimental work, several technological variants to enrich and separate the foam as an individual material fraction were investigated. The holistic aim is to minimise contamination from the foam in the valuable fractions. Two different types of foam and their effect on the purity of the recycling products were analysed.
Item
Open Access
Parametric Analysis Data on Boil-Off Rate and Holding Time of Metallic Tanks Containing Ammonia
(Technische Universität Dresden, 2025-05-22) Christoff, Bruno
This dataset was generated using a Simulink model developed as part of a digital platform to support the conceptual design of ships utilizing ammonia. The model simulates a metallic tank filled with ammonia under an initial predefined pressure and liquid volume fraction, analyzing its boil-off rate and holding time.
Item
Open Access
SPP 2020 - Numerical Benchmark - Fibre Analysis
(Technische Universität Dresden, 2025-05-14) Storm, Johannes
This repository contains codes to investigate CT data of fibre reinforced concrete as well as the determined fibre coordinates.
Item
Open Access
Data for: "PCL-based Drug Delivery System allows high antibiotic loading while maintaining cytocompatibility and antibacterial activity"
(Technische Universität Dresden, 2025-05-13) Guder, Celine; Hoffmann, Anja; Sterzenbach, Torsten
The present dataset encompasses images of PCL-based drug delivery systems subsequent to their fabrication. Moreover, it comprises raw data as well as processed data of UV/Vis measurements, which are employed to ascertain antibiotic concentrations. The dataset incorporates data from antimicrobial testing and the determination of minimal inhibitory concentrations via agar diffusion tests. Additionally, it encompasses data from assays of cellular toxicity with smooth muscle cells.